General Secretary Xi Jinping emphasized at the Yangtze River Delta Integrated Development Symposium in 2020 that the Yangtze River Delta should "be the pioneer of China's technological and industrial innovation." This article first shows through statistical data analysis that Jiangsu has developed industries and active enterprise innovation, but relatively insufficient investment in fundamental R&D. In addition, regional innovations along the Shanghai-Nanjing route are closely linked, and high-tech industries are in a trend of regional agglomeration. Next, this article analyzes the problems in the construction of the Shanghai-Nanjing Industrial Innovation Belt: Fundamental research investment lags behind industrial applications; There are factors hindering innovation, and it is urgent to take the lead in exploring provincial integration; The system and mechanism of the subject's collaborative innovation need to be further optimized in order to better solve the connection problem of the innovation link; Lack of a number of world-class industrial clusters, and lack of leadership in regional science and innovation industries. Finally, this article provides corresponding suggestions for vigorously promoting the development along the Shanghai-Nanjing Industrial Innovation Belt: 1. Exploring the institutional arrangements for transforming competitive assessment into collaborative assessment. 2. Establish a benefit-sharing mechanism for innovation achievements to fully stimulate the enthusiasm of the subjects of production, education and research. 3. Build an intermediary market for the transformation of scientific and technological services, and use market mechanisms to promote the deep integration of the innovation chain and the industrial chain. 4. Expand the radiation scope of "Shanghai-Nanjing Industrial Innovation Belt" and form resonance and interaction with the "G60 S&T Innovation Valley".
